"Fascinating" - mr. spock
genome and epigenome editing
for nearly a decade, the lab has developed robust reagents and methods that enable targeted genome editing, including: zinc finger nucleases, tale nucleases, crispr/cas nucleases, and base editors.
we have shown the utility of these platforms for targeted epigenome editing, through histone modification and heterotopic activation to alter gene expression.
together, we and our collaborators have created genome and epigenome edits with high efficiencies in zebrafish, plants or human somatic and pluripotent stem cells.
genome-wide assays: specificity
to understand the safety of genome editing technologies as potential therapeuties, we have developed assays such as guide-SEQ AND CIRCLE-SEQ THAT AIM TO DEFINE and detect OFF-TARGETS.
as a lab
we continue to create novel cutting-edge technologies and explore high-throughput genome- and epigenome-editing capabilities
we encourage interested undergraduate students, graduate students, and scientists from all backgrounds to inquire about opportunities to join our lab!!
See available plasmids at: https://www.addgene.org/Keith_Joung/
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