"Fascinating" - mr. spock

RESEARCH

RESEARCH

RESEARCH

RESEARCH

genome and epigenome editing

for nearly a decade, the lab has developed robust reagents and methods that enable targeted genome editing, including: zinc finger nucleases, tale nucleases, crispr/cas nucleases, and base editors.

we have shown the utility of these platforms for targeted epigenome editing, through histone modification and heterotopic activation to alter gene expression. 

 

together, we and our collaborators have created genome and epigenome edits with high efficiencies in zebrafish, plants or human somatic and pluripotent stem cells.

genome-wide assays: specificity

to understand the safety of genome editing technologies as potential therapeuties, we have developed assays such as guide-SEQ AND CIRCLE-SEQ THAT AIM TO DEFINE and detect OFF-TARGETS.

as a lab

we continue to create novel cutting-edge technologies and explore high-throughput genome- and epigenome-editing capabilities

we encourage interested undergraduate students, graduate students, and scientists from all backgrounds to inquire about opportunities to join our lab!!

email: jjoung@mgh.harvard.edu

 

See available plasmids at: https://www.addgene.org/Keith_Joung/

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J. Keith Joung

Massachusetts General Hospital
149 13th Street, 6th floor
Charlestown, MA 02129

E-mail: jjoung@mgh.harvard.edu

Website created by Joy Horng